Answer the following problems.

problem 1) How are molecular interactions simulated? Describe with the help of appropriate ex.

problem 2) How are binding sites in protein located? Describe with the help of suitable ex.

problem 3) How are protein structures predicted? Add an explanatory note on classification of protein structures.

problem 4) Describe the following:

a) Ramachandran plot

b) Protein folding -structure function relationship.

problem 5) prepare a detail notes on the following:

a) Bioinformatics business models.

b) Computer based research.

c) Role of bioinformatics in drug designing.