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Which of these statements about signal transduction is false:

A. Information from the outsideof the cell can be transmitted to the nucleus
B. G-protein coupledreceptors move to the nucleus upon ligandbinding.
C. Receptor tyrosine kinases, when bound by a ligand,phosphorylate substrates on the cytosolic side of theplasma membrane
D. Rapid elevation of cytosolic calcium  ionstriggers many cellular responses including activation ofenzymes.

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