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Which of the following best defines why the two DNA polymerase proteins that are held by the sliding clamp are oriented in opposite directions?

A. The efficiency of replication is enhanced if the two DNA polymerase molecules synthesize the templates in the opposite directions.

B. DNA polymerase is like large protein complex that steric hindrance stops both polymerases from following the replication fork. 

C. DNA polymerase can only read the template in the 3' to 5' direction and the template strands are  aligned with respect to each other in an anti-parallel orientation.

D. None of the above  

 

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