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What is the role of DNA gyrase in transcription?

a. It assists in the formation of termination hairpin structures.
b. It melts the DNA duplex to form the transcription bubble.
c. It removes the positive supercoils generated ahead of RNA polymerase.
d. It breaks the hydrogen bonds between DNA and RNA during transcription termination.
e. It removes the negative supercoils generated behind RNA polymerase.

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