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What is most likely to happen to an animal's target cells that lack receptors for local regulators?

What is most likely to happen to an animal's target cells that lack receptors for local regulators?

They could develop normally in response to neurotransmitters instead.
They might compensate by receiving nutrients via a factor.
They could divide but never reach full size.
They might not be able to multiply in response to growth factors from nearby cells.
Hormones would not be able to interact with target cells.

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