Ask Question, Ask an Expert

+1-415-315-9853

info@mywordsolution.com

Ask Biology Expert

You know that Cytosine can spontaneously delaminate to Uracil in DNA. dCTP, a substrate for the synthesis of DNA, can as well spontaneously delaminate to dUTP. E. coli has an enzyme called Dut (dUTPase) whose job it is to get rid of any dUTP in cell. Mutations which cause loss of Dut are LETHAL in strain that is as well missing RecA. (In other terms, a dut- mutant is alive, a recA- mutant is alive, but the dut- recA- mutant is dead.) An additional mutation in gene encoding Ung, the Uracil N-glycosylase which removes Uracil from DNA, restores viability to the dut- recA- double mutant. (The dut- recA- ung- triple mutant is alive.)

What is mechanism of lethality in mutant that lacks Dut and RecA and why is this lethality suppressed by loss of the Ung?

Biology, Academics

  • Category:- Biology
  • Reference No.:- M915255

Have any Question? 


Related Questions in Biology

Is anolis cristatellus more closely related to anolis

Is Anolis cristatellus more closely related to Anolis occultus or Anolis evermanni?

The effect of low ph on enzyme activitydesign an experiment

The Effect of low pH on Enzyme Activity Design an experiment in which you will test the effect of an acidic fluid on enzymatic activity. (Recall: enzymes are proteins.) To complete this project, it may be useful for you ...

Cell cycle checkpoints are an important feature of a

Cell cycle checkpoints are an important feature of a dividing cell to reduce errors that can occur in various stages of the cell cycle. Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncon ...

Discuss the mechanisms and consequences of adh and

Discuss the mechanisms and consequences of ADH and aldosterone on the kidneys

Antropoligy online descution one paragraph and two

Antropoligy online descution One paragraph and two reply Patterns of Adaptation" How do humans adapt to environmental challenges? In this lesson, experts explore this question from many angles. The difference between acc ...

How many neutrons does element x have if its atomic number

How many neutrons does element x have if it's atomic number is 42 and it's mass number is 154?

Three questions with cited references1 describe how social

Three questions with cited references... 1. Describe how social and environmental factors impact human behavior. 2. Describe two-three causes of death related to human behavior. Have the governments' interventions been e ...

Urgent two immune system questionsactivated t-helper cells

URGENT: Two immune system questions: Activated T-helper cells aid in humoral immune responses by releasing cytokines which promote antibody production, phagocytosis, neutralization and apoptosis. Which parts of this stat ...

Discussion topicolder people die for a number of reasons

Discussion Topic Older people die for a number of reasons: cancer, heart failure, complications due to diabetes, stroke, Alzheimer's, etc. Often times, the way we live our lives affect not only how long we live but what ...

What does precautionary principle mean how would you apply

What does precautionary Principle mean. How would you apply the concept of the Precautionary Principle to the unrestricted allowance of endocrine disrupters in consumer products?

  • 4,153,160 Questions Asked
  • 13,132 Experts
  • 2,558,936 Questions Answered

Ask Experts for help!!

Looking for Assignment Help?

Start excelling in your Courses, Get help with Assignment

Write us your full requirement for evaluation and you will receive response within 20 minutes turnaround time.

Ask Now Help with Problems, Get a Best Answer

Section onea in an atwood machine suppose two objects of

SECTION ONE (a) In an Atwood Machine, suppose two objects of unequal mass are hung vertically over a frictionless

Part 1you work in hr for a company that operates a factory

Part 1: You work in HR for a company that operates a factory manufacturing fiberglass. There are several hundred empl

Details on advanced accounting paperthis paper is intended

DETAILS ON ADVANCED ACCOUNTING PAPER This paper is intended for students to apply the theoretical knowledge around ac

Create a provider database and related reports and queries

Create a provider database and related reports and queries to capture contact information for potential PC component pro

Describe what you learned about the impact of economic

Describe what you learned about the impact of economic, social, and demographic trends affecting the US labor environmen