One of the main symptoms of diabetes is a plasma hyperglycemia (elevated blood sugar). Average blood sugar values (usually around 100 mg/dL in a normal value) can increase in excess of 300 mg/dL in a diabetic. This leads to a high volume of urine production (diuresis) with glucose in the urine; however, GFR does not change in patients who have not yet reached the stage of diabetes induced renal disease. From what you know of how the kidney functions, answer the following:
a) what do you think the filtered load of glucose should be in a diabetic relative to a normal individual? Why?
b) why does glucose show up in the urine?
c) why does diabetes lead to a diuresis (increased urine flow)