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Question: Vitamin D resistant rickets is usually an X-linked dominant condition. The disease is caused by mutations the PHEX gene and results in bone deformity and bow leggedness.

Consider a cross between a male who has vitamin D resistant rickets and a female who has fully functional PHEX protein and does not express vitamin D resistant rickets. Please use the symbol d, to denote the allele with the fully functional gene, and the symbol D, for the mutated version of the gene.

What are the genotypes of the described male and female?
What is the probability a son of this couple will inherit vitamin D resistant rickets?
What is the probability a daughter of this couple will inherit vitamin D resistant rickets?

 

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