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The  Cori cycle

a)  Pyruvate formed from glucose is converted  to lactate by lactate dehydrogenase in the muscle cell.

b)  Lactate is released into  the blood and taken up by the liver.

c)  Lactate  is converted to pyruvate by  the  isoenzyrne of  lactate dehydrogenase using NAD+  as cofactor  in the liver.

d)  Pyruvate is converted to glucose by gluconeogenic mechanism in the liver and released into the blood where it can be used  as energy source for ~uscle  and other tissue.

 

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