1. Arginine
2. Leucine
3. Lysine
4. Alanine
5. Phenylalanine
1. Valine
2. Glutamate
3. Glutamine
4. Phenylalanine
5. Lysine
Additional T state HbS interact with the growing aggregation to form an insoluble fiber.
Val interacts with the "pocket" of a beta chain on another HbS.
R state Hb shifts to T state Hb
O2 decreases due to vigorous exercise or high altitude.