The cleavage of a peptide bond by chymotrypsin is caused by a nucleophilic attack by an active-site residue. Which of the following is true?
A. The reaction mechanism depends only on a Ser residue in the active site.
B. Ser is a strong nucleophile because of the action of Asp and His in the active site.
C. The Asp in the active site acts as the nucleophile to attack the peptide bone.