Suppose a receptor tyrosine kinase signaling pathway, which if upregulated too much leads to unwanted cell proliferation and tumorigenesis. describe whether the therapeutic approaches stated below would be effective. Describe your answer and focus it on the effect of therapeutic on signal transduction.
a) ATP analogue drug which binds ATP site in receptor kinase domain.
b) ATP analogue drug which binds ATP site in a MAP kinase kinase.
c) GTP analogue that binds Ras.
d) Viral expression therapy which leads to increased levels of SOS in the cell