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Situation in which a closed loop negative feedback system is  converted to an open loop system?  

  A.  A disease that destroys all the adenylyl cyclase and all the cAMP in the intracellular spaces of all the epithelial cells of the medullary collecting duct.

  B.  A disease that destroys all the G-proteins in all the epithelial cells of the medullary collecting duct.

  C.  A disease that destroys all the AQP2 Receptors in the basolateral membranes of all the epithelial cells of the medullary collecting duct.

 

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