Regarding control of gene expression in eukaryotes what, Ask an Expert

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1. Regarding control of gene expression in eukaryotes, what effect does the binding of transcription factors to upstream promoter elements (or "modules") and elements/modules in enhancers have on the efficiency of assembly of the basal transcription factors to the core promoter?

2. Mutations that convert proto-oncogenes such as ras to active oncogenes are dominant, but those that knock out tumor supressor genes are recessive. Assuming mutations are equally likely in oncogenes and tumor supressor genes, why does oncogene activation happen more easily than suppressor gene inactivation?

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