Question -  Please discuss the mechanisms that Pseudomonas aeruginosa, Staphylococcus aureus, Propionibacterium acnes and Streptococcus pyogenes utilize to cause disease on skin and in the eyes. You must state what disease these microorganisms cause. In addition, please list and explain the host immune defenses that the microbe would have to overcome to be successful at causing disease (Include a discussion what role personal hygiene plays in microbial skin and eye infections). Also, please list and explain what the microbes could contain that would allow them to overcome these host immune responses. Please explain how these infections could lead to more serious conditions such as endocarditis. (Hint: Discuss the relationship between local and systemic infections and septicemia.) Include a discussion what roles quorum sensing and sequential timing play in microbial skin and eye diseases.