Q1. Consider the HIV enzyme called protease. The amino acid residues at the active site are highly hydrophobic. In designing a drug that would bind to the active site and jam it, researchers should use which sort of molecule?

Q2. While a suicide victim was found, the coroner was not capable to remove the drug vial in clutched in his hand. Explicate the reasons for this. If the victim had been discovered three days later, would coroner have had the same difficulty? Clarify.