Problemusing the ames test we add a mutagen to auxotrophic, Ask an Expert

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Problem:

Using the Ames test, we add a mutagen to auxotrophic salmonella with mutations in the histidine pathway and rat liver extract to simulate metabolism.

Question: How would we know if the carcinogen is a human carcinogen or not?

I'm guessing that if a mutagen showed no growth without the rat liver extract, but then growth with the rat liver extract this would mean that it is a human carcinogen.

Question: Is this true? If yes, please explain.

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Biology, Academics

Category:- Biology
Reference No.:- M91148821

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