Problem:

True/False. If it is false, explain why.

1. The diverse chemistry of amino acid R groups allow proteins to directly perform all biochemical transformation in the cell.

2. Enzymes accelerate biochemical reactions toward equilibrium by lowering the free energy of the transition state between substrates and products.

3. Glyceraldhyde -3-phosphate dehydrogenase generates a phosphoryl bond with high transfer potential by phosphorolysis of a thioester.

4. The phosphoglycerate kinase reaction generates the first net gain in ATP for glycolysis

5. To synthesis glucose from pyruvate, the cell ruins most glycolytic enzymes in reverse with the exception of three regulated enzymes that are bypassed with four gluconeogenic enzymes.

Justify your answer one by one.