Problem:

This patient's presynaptic neuron (nerve) action potentials and conduction velocities are normal. New information: With repeated stimulation of the efferent nerve to the arm and hand, the neuron action potentials remain normal, however there is a decline in muscle force production (as indicated by the weakness and fatigue in the arm and hand) over time, meaning that the post-synaptic response is decreasing with repeated stimulation.

Based ONLY on the information given above (in other words, don't look below to the next questions), consider what you know about the neuromuscular junction (presynaptic motor neuron axon terminals, cleft, motor end plate) and the process of muscle fiber contractile force production and suggest two specific separate abnormalities of the neuromuscular junction (NMJ) and two specific separate abnormalities of the muscle fiber (unrelated to NMJ) itself that could lead to the reduced force of contraction despite the normal APs and conduction velocity in the motor neurons.

Rdequired:

Question: Give a brief explanation for how each abnormality you have suggested would lead to decreased force production (weakness).

please provide correct answer..