Problem:

Steroid hormones are known to increase the expression of specific genes in selected target cell types. Testosterone increases the production of a protein called alpha-2-microglobulin (?2m) in the liver and hydrocortisone (a glucocorticoid) increases the production of tyrosine aminotransferase (TAT) in the liver. (Each hormone does many other things). All steroid hormone receptors consists of 3 related, but distinct, protein domains: a hormone binding domain, a DNA binding domain, and a regulatory domain.

Required:

Question 1: How is it that testosterone and hydrocortisone can selectively influence the expression of two different genes in the same tissue?

Question 2: By what you know of domains, suppose you carry out a domain swap experiment to exchange the DNA binding domains of testosterone receptor and glucocorticoid receptor with each other. What effects would you now expect the two hormones to have in cells containing the altered receptors?

Please Explain don't just write the answer.