Problem:

Question: Which of the following provides an explanation for why DNA in both prokaryotic and eukaryotic cells is negatively supercoiled

A)Because all DNA is circular and has to be negatively supercoiled to prevent kinks

B) Neg. supercoils make the seoarate strands in coiled DNA more compact for histone binding

C) Neg. supercoils make it easier to separate or unwind the DNA into single strands

D) Neg and positive supercoils have the same effect; they prevent DNase degradation

E) All of the above F)Answers 3 and 4

Please answer the correct answer and please explain also.