Problem:

Question: Which of the following contributes to preventing more than one ovum or follicle from maturing at the same time?

1. The FSH surge inhibits follicle maturation for any follicles remaining in the ovary
2. Increased androgen production by the thecal cells directly inhibits the granulosa cells.
3. A rise in estrogen and inhibin during the follicular phase of the ovarian cycle.
4. This is regulated by a circadian cycle

Give reasoning with your answer.