Problem:

Question 1: What residue of topisomerase enzymes is important for interacting with the phosphodiester bond?

A) Serine

B) Leucine

C) Threonine

D) Arginine

E) Tyrosine

F) Lysine

G) Phenylalanine

Question 2: During the process of transcription RNA polymerase goes through sweveral conformational changes. The closing of ___________ creates the exit channel for the mRNA.

A) Jaws

B) Door

C) Flap

D) Rudder

Provide the correct answer and justification for your choice.