Problem:

Question 1: What is the physiology of diarrhea? Why can it be bad? Please explain in detail.

Question 2: When glucagon binds to receptors on mammalian liver cells, it activates Protein Kinase A. This kinase will phosphorylate regulatory enzymes and have which of the following impacts on metabolism?

A. activation of Phosphofructokinase 2 followed by activation of glycolysis

B. activation of glycogen phosphorylase and activation of glycogenolysis

C. activation of Phosphofructokinase 1 followed by activation of gluconeogenesis

D. inhibition of glycogen phosphorylase followed by inhibition of glycogenolysis

E. activation of Phosphofructokinase 1 followed by inhibition of glycolysis

Provide the correct answer and justification for your choice.