Problemquestion 1 what exactly at the molecular level is, Ask an Expert

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Question 1: What exactly at the molecular level is itching?

Question 2: What physiological function does itching serve, if any?
I can't remember the reference but a PLCb3 null mice lost the itch phenotype, so presumably it is mediated by the Gq-PLCbeta pathway through a cell surface GPCR. Since a physical action of scratching relieves it,

Question: Could it be a case of a mechanosensitive channel at work?

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Category:- Biology
Reference No.:- M91146584

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