Problem:

Question 1: Functional domain loops can be seen by viewing _______ chromosomes with light microscopy.
a. normal interphase
b. lampbrush
c. metaphase
d. anaphase

Question 2: Sites of newly replicated DNA can be detected with antibodies if the DNA is labeled with
a. tritiated thymidine.
b. tritiated uridine.
c. bromodeoxyuridine.
d. bromodeoxythymidine.

Question 3: Newly replicated DNA is located in a few hundred spots in the nucleus because there are
a. a few hundred origins of replication per nucleus.
b. a few thousand origins of replication but only a few hundred are active at any one time.
c. a few thousand origins of replication active at any one time, but they are located in a few hundred discrete clusters.
d. None of the above

Question 4: Splicing of pre-rRNA produces
a. the 28S rRNA.
b. the 18S rRNA.
c. both 28S and 18S rRNAs.
d. None of the above

Question 5: What is the function of karyopherins?
a. They attach to chromosomes in order to activate heterochromatin.
b. They coat chromosomes.
c. They define the structure of Cajal bodies.
d. They transport macromolecules into or out of the nucleus.

Question 6: Which of the following is a possible intermediate during pre-rRNA processing?
a. An RNA molecule containing 18S + 5.8S rRNAs
b. An RNA molecule containing 5.8S + 28S rRNAs
c. An RNA molecule containing 5S + 28S rRNAs
d. An RNA molecule containing 18S + 28S rRNAs

Please provide the best option.