Problem:

Question 1: Assuming the PAV allele is the original one, what types of mutations (silent, missense, nonsense, etc.) have changed the PAV allele into the AVI allele? Explain. Based on the information given, how do these changes fit with what you have learned about the "functional enzyme hypothesis"?

Question 2: Describe the effect that acetylcholine has on the nerve-muscle junction and the pathways leading to contraction within the sarcomere?

Please read all the questions carefully and answer them.