Problem:

Question 1: A group of Ethiopians were assayed for CCR5-del32 deletion polymorphism. 247 were +/+, 69 were +/del32, and 11 were del32/del32. Are the observed data significantly different from HWE? If not, what might explain the pattern. Please show your work.

Question 2: Industrial melanism refers to the dark pigmentation that evolved in some insects giving them protective coloration on vegetation darkened by soot in heavily industrialized areas prior to air pollution regulation. Assume that in one heavily polluted area near Birmingham, England in 1956, 79% of the moths of the species Biston betularia were black due to the presence of a dominant gene for melanism. Estimate the frequency of the dominant allele in this population, and the proportion of black moths that are heterozygous.Show your all work.