Problem:

Place the following labels in the proper position to designate what effect each condition would have on membrane physiology.

Categories:

i.      Makes RMP (Resting Membrane Potential) Less Negative

ii.      Influences the Ability of the Cell to Repolarize

iii.     Influences the Ability of the Cell to Depolarize

Place in the three categories above:

a) Voltage regulated potassium channels are blocked

b) Decreased concentration of leaky potassium channels in the membrane

c) Acetylcholine esterase concentration is decreased

d) ATP stores are declining through mitochondrial poison (arsenic)

e) The size of the synaptic cleft is increased

f) Hyper hydration (high water concentration in ECF)

g) Release of excitatory neurotransmitter by a presynaptic input is blocked

h) Hyponatremia (low ECF sodium)

i) Neurotransmitter synthesis is compromised due to Golgi dysfunction in the presynaptic neuron

j) Increased concentration of leaky sodium channels in the membrane.

Please place the following statements in the above three categories and justify your answer.