Problem:

It is well known that the first DNA polymerase, Taq, is quite error prone. Newer generation commercial enzymes that have either been isolated from different thermophile species or have been improved by recombination are less error prone.

Question: How are these error rates compared? Explin.

For instance, if this is done by Sanger sequencing, the average signal will dominate in reading the output and so it will be very unlikely to pick up on errors by this method.