Problemi am reading a paper which discusses a complex, Ask an Expert

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Problem:

I am reading a paper which discusses a complex (MSL-DCC) involved in dosage compensation of the drosophila X-chromosome. Descriptions of the complex's structure and function are given in the papers introduction.

Required:

Question: What is chromatin shearing?

Question: What is happening during the process?

Secondly, the authors then say:

"Our data suggest that the complex is particularly sensitive to shear forces on transcribed chromatin so that only the direct interactions on MSL-3 with nucleosomes are retained" - discussion section (subheading: interaction of the MSL-DCC with target gene bodies)

Required:

Question: Could someone explain what is meant by 'particularly sensitive to shear forces'? In comparison to what?

Question: What are the consequences of it being more sensitive?

Any ideas? Or better yet, pointers to places where this has already been answered

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Biology, Academics

Category:- Biology
Reference No.:- M91162795

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