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Problem:

I am planning to utilize a new system in our lab, in which I will co-culture cancer cells from different tissues with fibroblasts. I have the option to receive skin-derived primary fibroblasts. I have been told the normal fibroblasts are very similar all over the body.

Question: Is this really true? I assume that fibroblasts secrete factors, for example, that are tissue specific.

Question: How quickly do they adapt to a new environment?

For example if I take these skin-derived fibroblasts and co-culture them with breast cancer cells,

Question: How long will it take the fibroblasts, if any, to become more like fibroblasts derived from the breast?

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  • Category:- Biology
  • Reference No.:- M91162132

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