Problem:

I am computer scientist working on machine learning methods applied to predicting missing Gene Ontology annotations. In many papers, I wrote that my computational methods are very useful to suggest to the biologists on which gene functions they should address their research, because my software need less resources (a simple laptop connected to a database) and less time (e.g. with a dataset of all the Homo sapiens Gene Ontology annotations: about 3 hours) than their biological experiments.

Required:

Question 1: Now a reviewer asked me to be more precise. Truly, how much does an in vitro experiment to biologically validate a human Gene Ontology annotation run by biologists cost?

Question 2: How much money, broadly?

Question 3: How much time?

Please provide discription of all the answers.