Problema study looked at mutations in the hydrophobic core, Ask an Expert

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Problem:

A study looked at mutations in the hydrophobic core of a protein of interest. The Tm for the wild-type protein (no mutations) was compared with that of a few site-directed mutants. The data is shown below:

Wild-type 53.5 oC

L46A 43 oC

L118A 40 oC

L99A 36 oC

Question: Why do all of these mutants substitute alanine for the naturally-occurring amino acid?

Explain your reasoning.

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Biology, Academics

Category:- Biology
Reference No.:- M91165421

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