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Question: Normally multicopy plasmids do not integrate into the chromosome even when they contain considerable DNA sequence homology for recombination. Gutterson and Koshland (1983. Proc. Natl. Acad. Sci. USA 80: 4894-4898) showed that multicopy plasmids (such as pBR322) readily integrate into the chromosome of polA (encodes DNA polymerase I) mutants. Suggest an explanation for both of these results.

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Category:- Biology
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