Myocardial contractility is mostly dependent on the level, Ask an Expert

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Myocardial contractility is mostly dependent on the level of sympathetic nerve activity and is also increased by circulating catecholamines and inotropic drugs like dopamine and dobutamine. With increased contractility there is an increased oxygen demand which is out of proportion to the extra work performed. These factors become critical when there is a decrease in oxygen supply as with coronary artery disease.

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