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Mechanistic description for the finding that is consistent with all the data related to transfer of immunologically competent T-lymphocytes from a donor into a host expression causing graft versus host disease (GVH). 

The transmission of immunologically competent T-lymphocytes from a donor into a host expression different MHC antigens can have severe consequences, affecting a fatal syndrome called graft versus host disease (GVH). The subsequent table explores a ran model of GVH, it displays the minimum number of parental strain t- cells that cause fatal GVH in various treatment groups of F1 hybrid off spring derived from mating of two MHC different strain, a and b.

 

 

Minimum number of A or B strain t- cells which cause lethal GVH in the AxB F1 106

 

Group

(A X 2) F1 hosts age and treatment

Strain A T cells

Strain B t cells

1

Intreated new born F1

5

5

2

Untreated adult f1

1000

1000

3

Adult F1 given 300 rad irradiation or an anti - proliferative drug

5

5

4

Adult F1 immunized with 10 of the strain parental t - cells and then irradiated as in group 3

1000

5

5

Adult F1 immunized with 107 a strain t- cells taken from donors that had previously been made tolerant to MHC of B, and then irradiated as in group 3.

5

5

Provide a mechanistic explanation for the finding that is consistent with all the dat1) describe your reasoning.

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  • Category:- Biology
  • Reference No.:- M917488

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