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Many eukaryotes have a DNA glycosylase that specifically removes T residues from DNA, but only when they are paired with G. There is no comparable enzyme that removes the G residues from G-T mismatches. Why is it useful for a cell to always repair a G-T mismatch to G-C rather than to a A-T? Hint: there are two very common sources of G-T mismatches that we discussed.

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