Low blood glucose is detected by the pancreas that subsequently releases glucagon a hormone that has wide spread effects including the activation of gluconeogenesis in the liver. Given this information predict the affect of gluconeogenesis activation on the following processes in the liver. (State increasing or decreasing for A-C)

A. Rate of malate production in the mitochondria (up or down)

B. Glucose export (excretion) out of the liver cell (increasing or decreasing)

C. Predict the effects that a cytosolic malate dehydrogenase inhibitor would have on the rate of glucose production in the liver (up or down)

D. Explain why you think this is the case in part C