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Lesch-Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.

Part A
What is the probability that the first son of a woman whose brother has Lesch-Nyhan syndrome will be affected?
Express your answer as a fraction (example 1/16).

Part B:
If the first son of the woman described in (a) is affected, what is the probability that her second son is affected?
Express your answer as a fraction (example 1/16).

Part C
What is the probability that the first son of a man whose brother has Lesch-Nyhan syndrome will be affected?
Express your answer using one decimal place.

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  • Reference No.:- M9397511

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