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Kruppel and giant are 2 gap genes in drosophila for which the maternal effect gene bicoid serves as a transcriptional activator. Bicoid protein is present in an concentration gradient in the drosophila embryo, with the highest levels at the anterior end and progressively lower levels as one moves toward the posterior pole.

a) In general terms , what phenotype is expected of a mutation producing non-functional kruppel protein?

B) The expression domain of giant is anterior to that of kruppel with little overlap between the two. List 2 general types of gene regulatory mechanisms that contribute to these differences in expression pattern between giant and krupel.

c) hedgehog is an ex of a segment polarity gene in drosophila. Would one expect any alterations of kruppel expression in embryos mutant for hedgehog? Why or why not?

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