Imagine a population in which an autosomal recessive disease mutation has an allele frequency of 0.04 (q = 0.04).
4A. What is the frequency of the disease in the population if the population is in HWE?
4B. If the population decides to regularly inbreed using brother-sister mating pairs (F = 0.25), what will be the frequency of the disease in the population when the population eventually arrives at equilibrium?
4C. Going back to the original population, if the environment changes in such a way that natural selection begins to work against the affecteds, to where the fitness of the MM genotype = 0.3, and the fitness of the NN and NM genotypes are both 1.0, what will the frequency of the disease be in the population after it reaches equilibrium?