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1. If we wanted to produce human insulin or human blood clotting factor in bacteria, what problems might we encounter?

2. If a patient had a defective gene for insulin or blood clotting factor and we wanted to replace the patient's defective gene with a functioning gene for human insulin or blood clotting factor, what problems might we encounter?

3. Do you expect that somatic cell gene therapy and germ-line gene therapy for the same disease will be equally difficult?

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