Epidemiology at the CDC in Atlanta, GA have called you in to investigate and increased incidence of leukemia in a remote region of Africa. Shortly after arriving, an RNA virus was isolated from patients and found to induce leukemia in mice. At this point you don't know the mechanism or viral gene product associated with the developed of leukemia. one of your lab assistant has isolated a variant of the virus and reports that this variant is missing a portion of (20%) of the genome of the original virus. Furthermore, this variant does not induce leukemia in mice.
a) How would you determine which portion of the genome is associated with the development of leukemia?
b) How would you determine the viral mechanism and product associate with the development of leukemia.?