GENETIC PROBLEMS:

This is the base sequence on one strand of a certain DNA molecule:

3' T A C A A T G C C A G T G G T T C G C A C A T T 5'

1. Give the base sequence on the complementary DNA strand (the other side).

2. Give the base sequence of the strand of mRNA which would be constructed from the original DNA strand.

3. What amino acid sequence would this mRNA code for?

4. If the seventh nucleotide of the original strand of DNA were changed from G to C, what would the resulting mRNA read? Include the entire strand.

5. What would the resulting amino acid sequence be? Include the entire sequence. What type of mutation is this?

6. If a G were added to the original DNA strand after the 6th nucleotide, what would the resulting mRNA read? Include the entire strand.

7. What would the resulting amino acid sequence be? Include the entire sequence. What type of mutation is this?

8. If the 11th nucleotide on the original DNA strand were changed from G to C, what would the resulting mRNA strand read? Include the entire strand.

9. What would be the resulting amino acid sequence? Include the entire sequence. What type of mutation is this?

Consider the following DNA base sequence:

3' T A C C A C G T G G A C T G A G G A C T C C T C A C T 5'

10. What is the mRNA sequence that would result from this DNA sequence ?

11. What is the amino acid sequence that result from this mRNA sequence?

12. If the 8th nucleotide in the original DNA molecule were changed from T to A, what mRNA would the new DNA code for? Include the entire strand.

13. What is the amino acid sequence that would result from this mRNA sequence? What type of mutation is this?

SHORT ESSAY: This is the change that results in sickle cell anemia. Using your textbook as a reference, describe the occurrence of sickle cell anemia, the phenotype and genotype of the disease, and the relationship of sickle cell anemia and malaria.