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For each of the given, describe one genetic and one epigenetic change which could lead to cancer.   Select a specific gene and a specific alteration. describe the effects of the change and why it might contribute to the cancer. Each and every genetic or epigenetic change must be different (ex: you might use each kind of change only once.)

a and b. modifications to a gene encoding a protein included in apoptosis

c and d. modifications to a gene encoding a DNA damage repair protein

e and f. modifications to a gene encoding included in cell cycle regulation.

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