Ask Question, Ask an Expert

+1-415-315-9853

info@mywordsolution.com

Ask Biology Expert

describe studying and predicting the results of an experiment conducted with a mutant mouse.

A researcher newly discovered a mutant mouse with an interesting T cell phenotype. He named this new mutation: HD," bred the mouse as well as then used these founders to generate a strain homozygous for HD. Several of his finding are summarized in the table below:

 

Thymocytes

Lymph node t cells

 

CD4+8+

CD4+

CD8+

CD4+

CD8+

Wild typ

100

40

20

20

12

HD mutant

100

1

20

0.5

14

1. describe what he found.

2. He next made bone core chimeras, injecting bone marrow from HD mice into lethally irradiated wild type mice. They originate that thymocytes in these chimeras exhibited a staining pattern identical to that of HD mice. In contrast when they did the inverse, they originate that the thymocytes exhibited a normalCD4/CD8 phenotype. What do these outcomes tell you?

3. Founded on these results advance a hypothesis about the cause of the phenotype.

4. Founded on your hypothesis what do you predict would happen to developing T cell in an HD mouse that has been made transgenic for a TCR restricted to I- Ab. Describe your reasoning.

Biology, Academics

  • Category:- Biology
  • Reference No.:- M917494

Have any Question? 


Related Questions in Biology

Elaborate on the basic concepts involved in the regulation

Elaborate on the basic concepts involved in the regulation of fluids and electrolytes. Also, identify the hormones that play important roles in regulating fluid balance and electrolyte balance and describe their effects.

Which genetic material was discovered by robert brown and

Which genetic material was discovered by Robert Brown and in which year.

Essay - immunizationsthe biology concepts presented in this

Essay - Immunizations The biology concepts presented in this course are taught in a way that encourages you to make the connection between textbook biology and biology that appears in newspapers and periodicals. This ass ...

Research and briefly describe a real world example about

Research and briefly describe a real world example about acid rain affects plants. Be sure to demonstrate how pH contributes to the outcome, and proposed solutions. Descriptions should be approximately 2-3 paragraphs. In ...

What is the most common dna repair system in humans

What is the most common DNA repair system in humans, involving enzymatic functions and replacement of damaged DNA bases?

1 mediterranean climates like those in central california

1. Mediterranean Climates, like those in Central California, experience extremely hot and dry summers and relatively cool and moist winters. Relate the soil-water balance to the growth strategies of plants in this region ...

What is the process of dna replication please include

What is the process of DNA replication? Please include descriptions and possibly diagrams to further explain the process.

Microbiology1 for what specific purpose was gram staining

Microbiology 1. For what specific purpose was gram staining developed for? what is it used for today? 2. Why is the presence of air bubbles a sign of contamination? 3. Why is a gram stain helpful when monitoring bacteria ...

Define nonrenewable resources and identify four examples

Define nonrenewable resources and identify four examples (only one energy source allowed).

Imagine two parents are both heterozygous for two autosomal

Imagine two parents are both heterozygous for two autosomal genes. Assuming independent assortment, what proportion of their offspring are expected to have the same phenotype (for these two traits) as the parents? A) 0.2 ...

  • 4,153,160 Questions Asked
  • 13,132 Experts
  • 2,558,936 Questions Answered

Ask Experts for help!!

Looking for Assignment Help?

Start excelling in your Courses, Get help with Assignment

Write us your full requirement for evaluation and you will receive response within 20 minutes turnaround time.

Ask Now Help with Problems, Get a Best Answer

Section onea in an atwood machine suppose two objects of

SECTION ONE (a) In an Atwood Machine, suppose two objects of unequal mass are hung vertically over a frictionless

Part 1you work in hr for a company that operates a factory

Part 1: You work in HR for a company that operates a factory manufacturing fiberglass. There are several hundred empl

Details on advanced accounting paperthis paper is intended

DETAILS ON ADVANCED ACCOUNTING PAPER This paper is intended for students to apply the theoretical knowledge around ac

Create a provider database and related reports and queries

Create a provider database and related reports and queries to capture contact information for potential PC component pro

Describe what you learned about the impact of economic

Describe what you learned about the impact of economic, social, and demographic trends affecting the US labor environmen