Ask Question, Ask an Expert

+1-415-315-9853

info@mywordsolution.com

Ask Biology Expert

describe studying and predicting the results of an experiment conducted with a mutant mouse.

A researcher newly discovered a mutant mouse with an interesting T cell phenotype. He named this new mutation: HD," bred the mouse as well as then used these founders to generate a strain homozygous for HD. Several of his finding are summarized in the table below:

 

Thymocytes

Lymph node t cells

 

CD4+8+

CD4+

CD8+

CD4+

CD8+

Wild typ

100

40

20

20

12

HD mutant

100

1

20

0.5

14

1. describe what he found.

2. He next made bone core chimeras, injecting bone marrow from HD mice into lethally irradiated wild type mice. They originate that thymocytes in these chimeras exhibited a staining pattern identical to that of HD mice. In contrast when they did the inverse, they originate that the thymocytes exhibited a normalCD4/CD8 phenotype. What do these outcomes tell you?

3. Founded on these results advance a hypothesis about the cause of the phenotype.

4. Founded on your hypothesis what do you predict would happen to developing T cell in an HD mouse that has been made transgenic for a TCR restricted to I- Ab. Describe your reasoning.

Biology, Academics

  • Category:- Biology
  • Reference No.:- M917494

Have any Question? 


Related Questions in Biology

Sickle-cell anemia is caused by an abnormal hemoglobin

Sickle-cell anemia is caused by an abnormal hemoglobin molecule that changed the shape of red blood cells. This disease can lead to various health complications that are often lethal. However, heterozygous individuals ha ...

Identify the alga known for biological activity called

Identify the alga known for biological activity called bioluminescence?

Antropology book reviewanthropology 105book response value

Antropology Book Review Anthropology 105 Book Response (Value 20 points) Length: 750-1000 words, not including quotes or references Times New Roman Double spaced Late penalty: 1 point per day Review your worksheet respon ...

Contrast the different types of stem cells including pros

Contrast the different types of stem cells, including pros and cons of each.

A cell undergoing meiosis produces a daughter cell during

A cell undergoing meiosis produces a daughter cell, during which one nondisjunction event occurs. If the number of chromosomes in a normal diploid cell of this organism (not undergoing cell division) is 38, how many chro ...

A multicellular lifeform has a weird type of cell in its

A multicellular lifeform has a weird type of cell in its body. This cell has a high density of peroxisomes. What is the most reasonable function of this cell? Functions for redox reactions Functions for digestion Functio ...

What did the experiments by stanley miller demonstrate

What did the experiments by Stanley Miller demonstrate about the formation of the first organic molecules? Why was it significant?

1 severe combined immunodeficiency disease scid is fatal at

1. Severe combined immunodeficiency disease (SCID) is fatal at an early age. SCID is caused by the lack of the enzyme adenosine deaminase, which is encoded by the gene ADA. Suppose you want to use a gene therapy method t ...

Imagine two parents are both heterozygous for two autosomal

Imagine two parents are both heterozygous for two autosomal genes. Assuming independent assortment, what proportion of their offspring are expected to have the same phenotype (for these two traits) as the parents? A) 0.2 ...

In hiring a prospective employee there are legitimate

In hiring a prospective employee, there are legitimate reasons for not hiring someone. For example, the prospective employee may not meet legal requirements (i.e., he or she is a minor and cannot complete the tasks of th ...

  • 4,153,160 Questions Asked
  • 13,132 Experts
  • 2,558,936 Questions Answered

Ask Experts for help!!

Looking for Assignment Help?

Start excelling in your Courses, Get help with Assignment

Write us your full requirement for evaluation and you will receive response within 20 minutes turnaround time.

Ask Now Help with Problems, Get a Best Answer

Section onea in an atwood machine suppose two objects of

SECTION ONE (a) In an Atwood Machine, suppose two objects of unequal mass are hung vertically over a frictionless

Part 1you work in hr for a company that operates a factory

Part 1: You work in HR for a company that operates a factory manufacturing fiberglass. There are several hundred empl

Details on advanced accounting paperthis paper is intended

DETAILS ON ADVANCED ACCOUNTING PAPER This paper is intended for students to apply the theoretical knowledge around ac

Create a provider database and related reports and queries

Create a provider database and related reports and queries to capture contact information for potential PC component pro

Describe what you learned about the impact of economic

Describe what you learned about the impact of economic, social, and demographic trends affecting the US labor environmen