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DNA replication in early Drosophila embryos occurs about every 5 minutes. The Drosophila genome contains approximately 1.8 X 108 base pairs. Eukaryotic DNA polymerases synthesize DNA at a rate of approximately 40 nucleotides per second. Approximately how many origins of replication are required for this rate or replication? (Hint: remember that replication is bi-directional.)

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