Discuss common pathways of dna mutation ndash chemical, Ask an Expert

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How tissue/cells designed to protect and repair DNA:

Question: Discuss common pathways of DNA mutation – chemical [examples / deamination, alkylation, etc] – slippage during replication – keto/enol flux / physical energy.

Question: Discuss the repair mechanisms – methyl directed mismatch / nucleotide excision / base excision repairs / GST - and how mutation in them lead to inheritable risk for developing cancer.

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