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Discovery the concentration of caffeine required to interfere DNA replication

High amounts of caffeine interfere with the DNA replication checkpoint mechanism in mammalian cells. Why then do you presume the Surgeon General has not yet issued an appropriate warning to heavy coffee as well as soda drinkers? A typical cup of coffee (150 ml) contains 100 mg of caffeine (196 g/mol5). How numerous cups of coffee would you have to drink to reach the dose (10mM) need to interfere with the DNA replication checkpoint mechanism? (A usual adult contains about 40L of water.)

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